Metabolic Dysfunction-Associated Steatotic Liver Disease

Source:  DD News

 Context: Exercise is a cornerstone in managing metabolic dysfunction-associated steatotic liver disease (MASLD), according to a study led by an Indian-origin researcher.

  • Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), previously known as Non-Alcoholic Fatty Liver Disease (NAFLD), is a chronic liver condition linked to fat accumulation in the liver.

About Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD):

  • What it is: MASLD is a liver disease caused by excessive fat build-up in the liver, often linked to metabolic dysfunction. It can progress to inflammation (MASH) and severe complications like liver fibrosis or cirrhosis.
  • Causes:
  • Obesity (BMI ≥ 30).
  • Insulin resistance leading to poor blood sugar management.
  • Type 2 diabetes.
  • Dyslipidemia (high cholesterol and lipids).
  • Symptoms:
  • Fatigue and weakness.
  • Right upper abdominal ache.
  • Swollen belly and yellowing skin (in advanced cases).
  • Severe cases may lead to cirrhosis or liver cancer.
  • Diseases Associated:
  • MASH (inflammation with scarring).
  • Hepatocellular carcinoma (liver cancer).
  • Increased risks of cardiovascular diseases, breast cancer, and colon cancer.
  • Type 2 diabetes in non-diabetic individuals.
  • Treatment:
  • Lifestyle Changes: Weight loss and regular exercise to reduce liver fat and improve insulin sensitivity.
  • Dietary Adjustments: Avoiding high-fat, high-sugar foods.
  • Pharmacotherapy: For managing metabolic risk factors like diabetes and cholesterol.
  • Exercise Protocols: Tailored regimens can benefit all patients, including those with advanced liver disease like cirrhosis.

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