Source: TH
Context: Researchers at IIIT-Delhi have developed AgeXtend as a tool to efficiently cut down the time taken to identify viable molecules with geroprotectors, or age defying properties.
About AgeXtend:
- What it is:
- AgeXtend is an Artificial Intelligence-based platform designed to identify compounds with geroprotective (anti-aging) properties.
- Aim:
- To accelerate the discovery of molecules promoting healthy aging and longevity by cutting down the time and effort required in conventional research.
- Developed by:
- Researchers from the Indraprastha Institute of Information Technology (IIIT), Delhi.
- Procedure:
- Scans vast chemical spaces (1.1 billion compounds) to predict, analyze, and validate molecules with anti-aging potential.
- Utilizes machine learning to determine compounds’ efficacy, safety, and mechanisms of action.
- Experimental validation conducted on yeast, worms ( elegans), and human cell models.
- Significance:
- Largest study on longevity, encompassing commercial drugs, FDA-approved compounds, and Ayurvedic and Chinese medicine molecules.
- Provides a clear rationale for why certain compounds are identified as geroprotectors, aiding further targeted research.
- Open-source availability of code and data fosters collaboration among global researchers while enabling commercial exploration.
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