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safeEXO-Cas

 Context: Scientists at Columbia University College of Dental Medicine have developed a new gene editing platform called “safeEXO-Cas,” using exosomes as delivery vehicles for CRISPR/Cas9 components.

This platform enhances precision in targeting specific cells and tissues, overcoming the limitations of current delivery methods.

 

What are Exosomes?

Exosomes are naturally occurring vesicles that act as vehicles for transporting molecules, such as proteins and genetic material, between cells. These tiny membrane-bound structures play a crucial role in cell-to-cell communication and have potential applications in drug delivery, diagnostics, and therapeutics.

Structures of Exosomes
Structures of Exosomes

 

About CRISPR/Cas9 technology:

It is a genome editing tool, that works as a cut-and-paste mechanism on DNA strands, allowing targeted modifications to the genome. Its applications include editing genes in human embryos, improving crop resilience, and treating diseases like sickle cell disease.

safeEXO-Cas
safeEXO-Cas

 Source: Columbia University