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Reverse Transcriptase

Context: Researchers have discovered that the bacteria Klebsiella pneumoniae may use a newly identified protein, Neo, to counter bacteriophage infections. This protein, created through a process involving Reverse Transcriptase (RTs) and non-coding RNA, can halt the replication of both the bacterium and the invading bacteriophage, effectively stopping the infection.

What are RTs? 

Reverse transcriptase (RT) is an enzyme that synthesizes DNA from an RNA template. This process reverses the usual flow of genetic information, which typically goes from DNA to RNA to protein. RTs play a crucial role in the replication of retroviruses, like HIV, and are used extensively in molecular biology research and diagnostics to study and detect RNA viruses.

Reverse Transcriptase

This finding highlights the versatile role of reverse transcriptase in bacterial defence mechanisms and hints at potential applications in biotechnology and medicine, particularly in addressing antimicrobial resistance

Source: Th