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Facts for Prelims (FFP)


Source: TH


Context: Researchers have identified a new class of antibiotics, specifically zosurabalpin, with the potential to combat drug-resistant bacterium Acinetobacter baumannii.

  • This antibiotic was found to be effective against CRAB (carbapenem-resistant Acinetobacter baumannii)-induced pneumonia and sepsis in mouse models.
  • Zosurabalpin, a drug candidate, was developed through the optimization of a tethered macrocyclic peptide (MCP) that selectively kills A. baumannii.
  • The antibiotic’s unique mode of action involves inhibiting the transport of lipopolysaccharide (LPS), an essential process for creating the outer-membrane structure of Gram-negative bacteria.
  • Zosurabalpin blocks LPS transport, leading to the abnormal build-up of LPS in the cell and the subsequent death of the bacterium.