Facts for Prelims (FFP)
Source: TH
Context: Researchers from the Indian Institute of Science’s molecular biophysics unit have conducted a study revealing that peptides derived from the skin of Budgett’s frog possess the ability to combat enzymes produced by disease-causing pathogens.
- The frog’s skin secretions contain LL-TIL, a specific peptide studied by the researchers.
- LL-TIL was found to inhibit two key enzymes, subtilisin carlsberg and proteinase K, which are produced by pathogens and play a crucial role in promoting infections by breaking down specific protective proteins in the host.
The study provides insights into the inhibitory action of the frog-derived peptide, offering a potential framework for developing specific and potent inhibitors against various pathogenic enzymes.
About Budgett’s frog:
Budgett's frog (Lepidobatrachus laevis) is a species of frog in the horned frog family, Ceratophryidae.
Size: They can grow to be 4–5 in (10–13 cm) in size, with females being larger than males.
Habitat: Their natural habitat is the semiarid Gran Chaco region of South America.
