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Population-level genome sequencing

Facts for Prelims (FFP)


Source: TH

 Context: The UK recently completed sequencing half a million whole genomes, marking a significant milestone in population-scale genomics.

  • This approach offers unprecedented insights into human diversity and has transformative implications for various scientific fields.


Various large-scale genome programs are ongoing worldwide, including the U.S.’s AllofUS program, the European Union’s ‘1+ Million Genomes’ initiative, and the planned ‘Three Million African Genomes.’



  • Population-scale genome efforts serve diverse objectives, from understanding disease prevalence and biomarkers to informing therapeutic target discovery and supporting public health initiatives.

In Asia and India, initiatives like the GenomeAsia project and India’s GenomeIndia aim to conduct population-level sequencing, contributing to the broader understanding of human evolution, migration patterns, and adaptation to diverse environments

About Population-level sequencing (also known as population-scale sequencing)

 It is the process of sequencing the DNA or mRNA of multiple individuals of one or more species. This process uses probabilistic matching tools and large amounts of sequence information to identify genomes