Amyloidosis

Facts for Prelims (FFP)

 

Source: PIB

Context: Scientists from the Institute of Advanced Studies in Science and Technology have successfully fabricated a 2D protein monolayer using lysozyme molecules, a model protein for studying diseases like Amyloidosis.

  • Amyloidosis is a rare condition where the accumulation of amyloid protein in organs leads to dysfunction in vital organs such as the heart, kidneys, liver, spleen, nervous system, and digestive tract.
  • The study investigated the physical properties of lysozyme molecules at the air-water interface under varying surface pressure and subphase pH conditions.
  • The compressible behaviour of lysozyme monolayers was correlated with the formation of stripe-like domains with increasing surface pressure.

 

Lysozyme is a naturally occurring enzyme that protects against bacteria, viruses, and fungi. It’s found in many bodily secretions, including:

 Tears, Saliva, Milk, Sweat, Mucus, Egg white, Nasal mucus, Gastric secretions