Facts for Prelims (FFP)
Source: HT
Context: Hemochromatosis is a rare genetic disorder characterized by iron overload, which can lead to severe dysfunction in various organs.
- There are two main types of hemochromatosis: hereditary hemochromatosis and secondary hemochromatosis.
About Hemochromatosis:
Hereditary Hemochromatosis: This genetic disorder results from a mutation in the HFE gene, causing individuals to absorb excessive iron from their diet.
Unlike the body’s natural ability to regulate iron intake, people with hereditary hemochromatosis accumulate iron gradually in their system, which can lead to health problems over time.
The excess iron can affect vital organs such as the liver, heart, and pancreas, potentially causing cirrhosis, heart failure, diabetes, and arthritis.
Secondary Hemochromatosis: This type is typically caused by external factors like frequent blood transfusions, excessive iron supplementation, or certain medical conditions. Iron accumulation in secondary hemochromatosis can be more rapid and lead to organ dysfunction.
