Topic: Issues relating to development and management of Social Sector/Services relating to Health.
1) What do you understand by Fixed dose Drug Combinations (FDCs)? Discuss their merits and demerits. (250 words)
Why this question:
The article talks about FDCs, the question is to evaluate what are FDC’s, their advantages and disadvantages.
Key demands of the question:
Answer is straightforward and must explain in detail what are FDCs, their merits and demerits.
Discuss – This is an all-encompassing directive – you have to debate on paper by going through the details of the issues concerned by examining each one of them. You have to give reasons for both for and against arguments.
Structure of the answer:
In a few introductory lines define FDCs. – A Fixed Drug Combination is a formulation consisting of two or more
active pharmaceutical products combined in a single dosage form. It
consists of a pre-determined combination and dosages of respective drugs.
FDCs may be used to target a single disease or multiple
Discuss the following aspects in the answer:
Advantages of FDCs are:
- They reduce the pill burden by reducing the number of pills to be
- taken by the patients.
- They reduce the risk of adverse reaction compared to higher dose of monotherapy. They are believed to have higher efficacy compared to higher dose of monotherapy.
- They lead to reduction in overall cost and have least side effect.
Disadvantages of FDCs are:
- There may not be an FDC available with the exact required
- combination of drugs for the patient. This can lead to patients getting too much of a particular drug.
- If there is an adverse reaction from an FDC, it may be difficult to
- identify the ingredient responsible for causing the reaction.
- Pharmaceutical companies may also try to evergreen their patents by obtaining exclusive rights to sell an FDC, even though the patent for individual components have expired.
Conclude with their significance.