Topic– Science and Technology- developments and their applications and effects in everyday life
6)What to you understand by CRISPR Cas9 editing technology? There is growing fear that the promising gene-editing system is being prematurely rushed for clinical use. Discuss.(250 words)
Why this question
The article discusses the issue with one of the most important scientific progress and currently under intense focus of the science community – gene editing using CRISPR Cas9 technology. Understanding the technology along with its potentials and pitfalls is important for mains.
Key demand of the question
The question expects us to explain what this technology is and what it can do. Thereafter, it wants us to explain the potential applications of this technology which is causing the scientists to rush. Next we need to explain the potential issues that can crop up as a result of the application of this technology which suggests that we should proceed with caution. The way forward needs to be mentioned in the end.
Discuss – This is an all-encompassing directive – you have to debate on paper by going through the details of the issues concerned by examining each one of them. You have to give reasons for both for and against arguments.
Structure of the answer
Introduction – Explain what CRISPR Cas9 technology is.
- Explain the applications of gene editing in treating genetic diseases etc which makes the technology so lucrative to scientists. Give the advantages such as it has made gene editing simpler, faster and easily accessible to most laboratories.
- Highlight the issues as discussed in the article which should serve as a cautionary sign for us – CRISPR-Cas9-edited cells might trigger cancer, introduces unexpected off-target (outside of the intended editing sites) effects in mice, impact on P53 protein.
- Highlight how India is going ahead with research in this area
Conclusion – Discuss the way forward for this technology.